ISSN 1662-4009 (online)

ey0017.15-18 | (1) | ESPEYB17

15.18. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

HJ Watson , Z Yilmaz , LM Thornton , C Hübel , JR Coleman , HA Gaspar , J Bryois , A Hinney , VM Leppä , M Mattheisen

To read the full abstract: This genome-wide association study (GWAS) of 16,992 cases of anorexia nervosa and 55 525 controls identified 8 significant loci. The findings show that the genetic architecture of anorexia nervosa mirrors its clinical features, showing significant genetic correlations with psychiatric disorders (obsessive-compulsive disorder, depression, anxiety, and schizophrenia), physical activity, and metabolic (including glycemic), lipid and anthropometric trait...